Abstract:

Objective  To study the factors associated with prognosis of advanced nonsmall cell lung cancer(NSCLC)．Methods  Retrospective study was performed for clinical data of 234 patients with advanced NSCLC. The potential prognostic factors were evaluated by univariate and multivariate analyses. Results  Of 234 advanced NSCLC cases，six  factors such as gender，age，smoking status， performance status(PS)，pathological type and clinical stage were analyzed by univariate analysis， the results showed that the relative risk of PS was 1.980(95%CI  1.4822.646，P<0.05)，and the relative risk of smoking status was 1.355(95%CI  1.0291.784，P<0.05)， indicating PS and smoking status were related to the prognosis.Further multivariate analysis of the above two factors showed that the relative risk of PS was 2.085(95%CI  1.5552.796，P<0.05)，and the relative risk of smoking status was 1.464(95%CI  1.1091.934，P<0.05)，PS and smoking status were independent prognostic factors. Conclusion  PS and smoking are the independent factors associated with prognosis of advanced NSCLC．

Key words: carcinoma, nonsmallcell lung, prognosis, factor analysis, statistical