Abstract: Objective  To investigate the related factors of instent restenosis (ISRS) after stent implantation for vertebral artery stenosis.Methods  Totally 110 patients with vertebral artery stenosis who underwent stent implantation in our hospital from June 2015 to September 2018 were selected as the study group. The mean followup period was 15months. When the inner diameter stenosis of implanted segment was more than or equal to 50%, it should be regarded as restenosis.According to this, patients were divided into restenosis group (33 cases) and control group (77 cases).The clinical data, biochemical indexes and angiographic results were analyzed retrospectively in order to explore the relationship between them and ISRS of vertebral artery.Results  Multivariate logistic regression analysis showed that the risk factors of  ISRS included type 2 diabetes mellitus (OR=6.392, 95%CI 1.36130.032), stent length (> 13 mm )(OR=1.799, 95%CI 1.2092.678), primary vascular diameter (<3.5 mm)(OR=0.069, 95%CI 0.0130.383), variation of initial part of vertebral artery (OR=7.369, 95%CI 1.55834.860) and multiple stenosis(OR=8.985, 95%CI 1.33960.290).Conclusion  Type 2 diabetes, stent length  >13 mm,vascular diameter  <3.5  mm, the abnormality of initial part of the vertebral artery and its complication with multiple stenosisare major risk factorsfor predicting ISRS.It is necessary to pay more attention to the preoperative evaluation, followup and reexamination of patients with such risk factors.

Key words: vertebrobasilar , insufficiency； stent implantation, instent restenosis, risk factor