Abstract: Objective  To investigate the occurrence of gallbladder disease and its related risk factors in patients with hepatitis C virus(HCV). Methods  According to the results of color  ultrasound  report, 290 cases of HCV infection were divided into the group with  gallbladder disease (169 cases) and the group without gallbladder disease(121 cases). The clinical data disease of course,  body mass index(BMI),  negative emotion,  alcoholism history, total bilirubin(TBIL),  alanine aminotransferase(ALT), aspartate aminotransferase(AST),  γglutamyl  transpeptidase (GGT), serum albumin(ALB),  triglyceride(TG),  cholesterol (TC),  HCV viral load (HCVRNA) ,  portal vein width(PVW),  thickness of spleen and ascites were analyzed.The risk factors of gallbladder disease in  HCV  infected patients were explored. Results  The total incidence of gallbladder disease in 290 cases of HCV infection was 58.28% (169/290) .The disease course,  alcoholism  history,  TG,  GGT,  PVW and thickness of spleen of the group with gallbladder disease were higher than those without gallbladder disease(P<0.05).  Logistic regression analysis showed that alcoholism,  GGT and spleen thickness were independent risk factors for gallbladder disease in HCV infected patients. Conclusion  The incidence of gallbladder disease in patients with HCV infection was 58.28%. Alcoholism,  spleen thickness and GGT were independent risk factors for gallbladder disease in patients with HCV infection.

Key words: gallbladder disease; , hepatitis C virus; , risk factors