Effect of Buzhong Yiqi Decoction combined with FOLFIRI chemotherapy on immunity and inflammation in patients with colorectal cancer

doi:10.3969/j.issn.1004-583X.2021.08.011

Abstract

Abstract:

Objective To analyze the application effect of Buzhong Yiqi Decoction Combined with FOLFIRI chemotherapy in the treatment of colorectal cancer. Methods 80 patients with colorectal cancer in our hospital from January 2016 to January 2020 were selected and divided into two groups according to different treatment schemes. The control group was treated with FOLFIRI chemotherapy, while the observation group was treated with Buzhong Yiqi Decoction. Immune function index, inflammatory factor level, blood routine, liver and kidney function, clinical efficacy and quality of life score between groups before and after treatment were observed and analyzed.Results After treatment, total effective rate was significantly higher in observation group than in control group (P<0.05); significantly higher CD3⁺, CD4⁺, CD4⁺/CD8⁺ level were detected in groups and increase degree in observation group was even higher (P<0.05); significantly higher serum amyloid A(SAA) and C-reactive protein(CRP) in groups and the decline of which in observation group were lower than in control group (P<0.05); significantly lower platelet count and white blood cell count in groups were detected, which were more common to see in observation group (P<0.05); difference is no significant in liver function between groups before and after treatment (P>0.05). significantly decreased serum creatinine level in groups were detected and decreased degree in observation group was even lower (P<0.05); the quality of life and in groups were significantly improved and which in observation group were better (P<0.05); compared with control group, adverse reaction in observation group were lower (P<0.05). Conclusion FOLFIRI chemotherapy has a good therapeutic effect for patients with colorectal cancer; when combined with Buzhong Yiqi Decoction, it can further improve immunity and inflammatory reaction, improve quality of their life, reduce adverse reaction, which is a safe and effective and feasible for treatment.

Key words: buzhong yiqi decoction, FOLFIRI regimen, colorectal neoplasms, immunity, inflammatory reaction

CLC Number:

R735.34

Li Peipei, Cao Yang, Wang Haicun, Dui Weihua. Effect of Buzhong Yiqi Decoction combined with FOLFIRI chemotherapy on immunity and inflammation in patients with colorectal cancer[J]. Clinical Focus, 2021, 36(8): 730-734.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.08.011

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I8/730

Figures/Tables 7

References 22

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组别	例数	CD3⁺		CD4⁺		CD4⁺/CD8⁺
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	40	60.36±3.86	66.86±3.85^*	31.16±2.68	37.56±2.85^*	1.33±0.21	1.52±0.16^*
对照组	40	60.26±3.85	64.53±3.74^*	31.18±2.56	35.74±2.73^*	1.34±0.22	1.38±0.13^*
t值		0.116	2.746	0.034	2.917	0.208	4.295
P值		0.908	0.001	0.973	0.001	0.836	0.001

组别	例数	CD3⁺		CD4⁺		CD4⁺/CD8⁺
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	40	60.36±3.86	66.86±3.85^*	31.16±2.68	37.56±2.85^*	1.33±0.21	1.52±0.16^*
对照组	40	60.26±3.85	64.53±3.74^*	31.18±2.56	35.74±2.73^*	1.34±0.22	1.38±0.13^*
t值		0.116	2.746	0.034	2.917	0.208	4.295
P值		0.908	0.001	0.973	0.001	0.836	0.001

组别	例数	SAA		CRP
组别	例数	治疗前	治疗后	治疗前	治疗后
观察组	40	7.48±5.62	14.26±4.35^*	7.39±5.16	8.26±4.68^*
对照组	40	7.39±5.46	18.49±5.13^*	7.41±5.23	11.09±4.81^*
t值		0.073	3.678	0.017	2.667
P值		0.942	0.001	0.986	0.001

组别	例数	SAA		CRP
组别	例数	治疗前	治疗后	治疗前	治疗后
观察组	40	7.48±5.62	14.26±4.35^*	7.39±5.16	8.26±4.68^*
对照组	40	7.39±5.46	18.49±5.13^*	7.41±5.23	11.09±4.81^*
t值		0.073	3.678	0.017	2.667
P值		0.942	0.001	0.986	0.001

组别	例数	血小板计(×10⁹/L)		白细胞计数(×10⁹/L)
组别	例数	治疗前	治疗后	治疗前	治疗后
观察组	40	284.39±65.18	320.26±65.16^*	6.41±1.33	6.08±1.26^*
对照组	40	285.46±66.25	290.58±64.89^*	6.50±1.36	6.86±1.34^*
t值		0.073	2.041	0.299	2.682
P值		0.942	0.045	0.766	0.009