关键词: 高尿酸血症, 痛风, 心血管疾病, 代谢疾病

Abstract: Uric acid is the ending product of purine metabolism. Increased serum uric acid (SUA) affects the stability of atheromatous plaque and increases the incidence of myocardial infarction, heart failure and allcause mortality of patients with coronary heart disease (CHD). Especially in female patients, the incidence of CHD has increased significantly. Using normotensive children for comparison, the risk of showing prehypertension or hypertension increases by at least 50% for each 1 mg/L SUA increase in adolescence. The morbidity of hypertention in male is higher than that in female. Hyperuricemia (HUA) also adds the risk of diabetes, abnormal glucose tolerance and diabetic nephropathy. To some extent, HUA aggravates symptoms of metabolic syndrome such as insulin resistance, obesity or lipid metabolic disorders. Although HUA increases prevalence risk of cardiovascular disease, there is no consensus recommendation for the treatment of asymptomatic HUA at home and abroad.

Key words: hyperuricemia, gout, cardiovasculardiseases, metabolicdiseases