丹参川芎嗪联合尼莫地平治疗短暂脑缺血发作的临床疗效

doi:10.3969/j.issn.1004-583X.2016.12.015

临床荟萃

丹参川芎嗪联合尼莫地平治疗短暂脑缺血发作的临床疗效

1.湖北省妇幼医院内科，湖北武汉 430070；2.武汉协和医院神经内科，湖北武汉 430022

出版日期:2016-12-05 发布日期:2016-12-01
通讯作者: 通信作者：王晓君，Email：wangxiaojun62@aliyun.com

Clinical effect of Danshen Chuanxiongqin combined with Nimodipine in treatment of transient ischemic attack

1.Department of Medicine， Hubei Provincial Women and Children Hospital，
Wuhan 430070， China; 2.Department of Neurology， Wuhan Union Hospital， Wuhan 430022， China

Online:2016-12-05 Published:2016-12-01
Contact: Corresponding author: Wang Xiaojun， Email:wangxiaojun62@aliyun.com

摘要/Abstract

摘要： 目的探讨丹参川芎嗪联合尼莫地平治疗短暂性脑缺血发作（TIA）患者的优势。方法100例TIA患者采用随机化方法分为两组，试验组50例应用丹参川芎嗪+尼莫地平，对照组50例单用丹参川芎嗪，两组同服拜阿司匹林，监测患者治疗前、后（3周）血压、血浆同型半胱氨酸(Hcy)、血小板聚集率(PAG)及与脑供有关动脉（包括颈总、颈内动脉及椎内、外段动脉）搏动指数(PI)、阻力指数(RI)的变化，选择50例健康志愿者作为空白对照组。结果两患病组治疗前血压、PAG、Hcy及各PI、 RI与空白对照组比较，差异有统计学意义（P<0.05）；两组治疗前、后（3周）血压、PAG及各PI、IR比较差异有统计学意义(P<0.05)，治疗后上述各项指标比较差异无统计学意义(P＞0.05)；与治疗前比较，试验组治疗后血浆Hcy水平下降(P<0.05)，而对照组治疗前后比较差异无统计学意义(P＞0.05)。两组均未见明显药物不良反应。结论丹参川芎嗪联合尼莫地平在改善TIA患者脑供有关动脉血流动力学及血液流变学的同时，具有一定降压作用，且降低血浆Hcy水平是单用丹参川芎嗪所不及，药物安全度高，可能在防止H型高血压发生及脑梗死的一级预防中发挥较好作用。

关键词: 脑缺血发作, 短暂性；川芎嗪;尼莫地平

Abstract: ObjectiveTo explore the clinical effect of Danshen Chuanxiongqin combined with Nimodipine in treatment of transient ischemic attack (TIA).MethodsA total of 100 cases of TIA were selected and randomly divided into control (B) and treatment(A) groups. The patients in group B received Danshen Chuanxiongqin with aspirin， and those in group A got Danshen Chuanxiongqin combined with Nimodipine， and aspirin. The levels of blood pressure， blood plasma homocysteine (Hcy)， platelet aggregation (PAG) and pulse index (PI) and resistant index (RI) of related arteries (such as common carotid artery， internal carotid artery， internal vertebra artery， external vertebra artery) were measured before and after treatment. And 50 healthy volunteers served as blank control group. All data were processed by SPSS 16.0. ResultsThe levels of blood pressure， PAG and PI and RI of related arteries were obviously different before and 3 weeks′ after treatment in group B and group A than in blank control group(P＜0.05).Compared with pretreatment， the level of Hcy was greatly decreased after treatment in group A（P＜0.05)，and there was no statistic significant difference before and after treatment in group B（P＞0.05). There were few side effects in two groups. ConclusionThe therapy of Danshen Chuanxiongqin combined with Nimodipine can significantly improve hemodynamics and hemorheology of related arteries， and reduce the levels of blood pressure and Hcy. Meanwhile， the therapy is safe and may play an important role in preventing brain stroke.

Key words: ischemic attack, transient, tetramethylpyrazine, nimodipine

王晓君1，曹学兵2. 丹参川芎嗪联合尼莫地平治疗短暂脑缺血发作的临床疗效[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2016.12.015.

Wang Xiaojun1， Cao Xuebing2. Clinical effect of Danshen Chuanxiongqin combined with Nimodipine in treatment of transient ischemic attack[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.12.015.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2016.12.015

https://huicui.hebmu.edu.cn/CN/Y2016/V31/I12/1336

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丹参川芎嗪联合尼莫地平治疗短暂脑缺血发作的临床疗效

Clinical effect of Danshen Chuanxiongqin combined with Nimodipine in treatment of transient ischemic attack

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