临床荟萃

• 专题 • 上一篇    下一篇

非心源性胸痛治疗的现状及进展

  

  1. 陆军总医院 消化内科,北京 100700
  • 出版日期:2017-01-05 发布日期:2017-01-12
  • 通讯作者: 通信作者:韩英,Email:yh721303@sina.com
  • 作者简介:韩英,主任医师、教授、博士生导师。原北京军区总医院副院长、消化内科主任;中华医学会消化分会委员兼司库;北京医师协会消化分会常务理事;Gastroenterology,Gut中文版 副主编;Journal of Crohn's and Colitis中文版编委;Journal Digestive Disease,《中华消化杂志》等杂志编委。

Current management of noncardiac chest pain

  1. Department of Gastroenterology, the Army General Hospital, Beijing 100700,China
  • Online:2017-01-05 Published:2017-01-12
  • Contact: Corresponding author: Han Ying, Email: yh721303@sina.com

摘要: 非心源性胸痛(NCCP)是常见的功能性消化系统疾病。胃食管反流病(GERD)、食管动力障碍以及食管超敏是NCCP主要的潜在机制。GERD相关NCCP首选双倍剂量质子泵抑制剂(PPI)。肌肉松弛剂如钙通道拮抗剂、硝酸盐和西地那非以及疼痛调节剂对食管动力障碍和功能性胸痛的NCCP有一定效果。认知行为、催眠及团队疗法可能对NCCP有一定疗效。可根据个体化原则选择药物、内镜或手术治疗NCCP。

关键词: 胃食管反流, 药物疗法, 内窥镜, 外科手术

Abstract: Noncardiac chest pain(NCCP) is one of the most common functional gastrointestinal disorders. Gastroesophageal reflux disease(GERD), esophageal dysmotility and esophageal hypersensitivity are the main underlying mechanisms of NCCP. Doubledose proton pump inhibitor(PPI)  treatment is the first choice in patients with NCCP because GERD is the most common etiology. Muscle which relaxants act like calcium channel blockers, nitrates and sildenafil and pain modulators appears efficacious in both patients with NCCP due to esophageal dysmotility and those with functional chest pain. Cognitive behavioral therapy and other psychological techniques such as hypnotherapy, group therapy might be effective in NCCP patients. Endoscopic and surgical therapeutic options are available.

Key words: gastroesophageal reflux, drug therapy, endoscopes, surgery