关键词: 卒中, 脑缺血发作, 短暂性, 肠杆菌科, 微生物-肠-脑轴

Abstract: Ischemic stroke is the most common type of cerebrovascular disease and is the first cause of death in Chinese population. In recent years， gut microbiota and its metabolites were  found to be constant engaged in the pathophysiology process of strokerelated risk factors， such as hypertension， diabetes and atherosclerosis. Preclinical evidence illustrated that the gut microbiota affect stroke outcomes by modulating the migration of intestinal IL17 + γδT cells to the meninges. Further study demonstrated that strokeassociated pneumonia was caused by gutderived bacteria. In summary， current researches have reported the influence of gut microbiota on the occurrence and prognosis of stroke. In this review， we outline the association between gut microbiota and the risk factors of stroke， the occurrence of stroke events and strokerelated complications.

Key words: stroke；ischemic attack, transient；enterobacteriaceae；microbiotagutbrain axis