间充质干细胞治疗克罗恩病相关性肛周瘘管的meta分析

doi:10.3969/j.issn.1004-583X.2019.04.012

临床荟萃

间充质干细胞治疗克罗恩病相关性肛周瘘管的meta分析

1.邯郸市中医院急诊科，河北邯郸 056001； 2.玉溪市人民医院骨科，云南玉溪 653100

出版日期:2019-04-20 发布日期:2019-05-16
通讯作者: 吴玉怀，Email: 270160748@qq.com

Mesenchymal stem cells in treatment of perianal Crohn's disease--a meta analysis

1.Department of Emergency, Handan Hospital of Traditional Chinese Medicine, Handan 056001, China;
2.Department of Orthopaedics, People's Hospital of Yuxi, Yuxi 653100, China

Online:2019-04-20 Published:2019-05-16
Contact: Corresponding author: Wu Yuhuai，Email: 270160748@qq.com

摘要/Abstract

摘要： 目的系统评价应用间充质干细胞治疗克罗恩病相关性肛周瘘管的有效性和安全性。方法检索Pubmed数据库、Cochrane临床试验数据库、中国知网CNKI、中国生物医学文献数据库CBM和万方数据库，查找关于应用间充质干细胞治疗克罗恩病相关性肛周瘘管的有效性和安全性文献。结果依纳入标准，5个研究满足纳入标准，含436例患者，meta分析结果显示：间充质干细胞治疗效果高于对照组（RR=1.348，95%CI=1.057～1.719, P=0.016）, 需治人数（NNT）=8.78（95%CI=4.83～48.21）；高剂量组具有降低间充质干细胞疗效的趋势（RR=0.500，95%CI=0.128～1.953, P=0.319）；间充质干细胞治疗安全性高于对照组（RR=0.796，95%CI=0.417～1.519, P=0.489）。漏斗图及Egg检验显示未见明显发表偏倚，敏感性分析显示结果稳定。结论应用间充质干细胞治疗克罗恩病相关性肛周瘘管安全性高、疗效显著。

关键词: Crohn病, 间质干细胞, 肛周瘘管

Abstract: Objective To systematically evaluated the efficacy and safety of mesenchyme stem cells for treatment of perianal Crohn's disease. MethodsThe Pubmed, Cochrane Library, CNKI, CBM and Wan fang databases were searched to find studies reporting efficacy and/or safety of mesenchyme stem cells for the treatment of perianal Crohn's disease. Results According to the inclusion criteria, 5 studies met the inclusion criteria,including 436 patients. Meta analysis results showed that the therapeutic effect of mesenchymal stem cells was higher than that of control group (RR=1.348, 95%CI=1.0571.719, P=0.016), and number needed to treat(NNT)=8.78 (95%CI=4.8348.21). The highdose group showed a tendency to reduce the efficacy of mesenchymal stem cells (RR=0.500, 95%CI=0.1281.953, P=0.319). The safety of mesenchymal stem cells was higher than that of control group（RR=0.796，95%CI=0.4171.519, P=0.489). No publication bias were found and the outcome was stable by the sensitivity analysis. Conclusion Mesenchymal stem cells for the treatment of perianal Crohn's disease can improve healing and do not increase the adverse events.

Key words: crohn , disease；mesenchyme stem cell, perianal fistula

刘建伟1，刘建平2，吴玉怀2. 间充质干细胞治疗克罗恩病相关性肛周瘘管的meta分析[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2019.04.012.

Liu Jianwei1, Liu Jianping2, Wu Yuhuai2. Mesenchymal stem cells in treatment of perianal Crohn's disease--a meta analysis[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.04.012.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2019.04.012

https://huicui.hebmu.edu.cn/CN/Y2019/V34/I4/347

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间充质干细胞治疗克罗恩病相关性肛周瘘管的meta分析

Mesenchymal stem cells in treatment of perianal Crohn's disease--a meta analysis

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