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2018年日本《内镜下乳头大球囊扩张术临床实践指南》解读

  

  1. 河北医科大学第二医院 消化科,河北 石家庄 050000
  • 出版日期:2019-04-20 发布日期:2019-05-16
  • 通讯作者: 冯志杰,Email: zhijiefeng2005@163.com

JGES guidelines for endoscopic papillary large balloon dilation--an interpretation

  1. Department of Gastroenterology,the Second Hospital of Hebei Medical University, Shijiazhuang 050000,China
  • Online:2019-04-20 Published:2019-05-16
  • Contact: Corresponding author: Feng Zhijie, Email: zhijiefeng2005@163.com

摘要: 日本胃肠内镜学会应用一种新的科学方法制定出《内镜下乳头大球囊扩张术临床实践指南》,以其作为一个基础性指南。内镜下乳头大球囊扩张术(EPLBD)作为一种胆总管结石的治疗方式而被广泛应用。该领域的证据等级通常较低,在许多情况下,推荐等级多处于专家共识水平。与《乳头括约肌切开术临床实践指南》相对应,该指南包括6部分内容。①适应证:单独应用乳头括约肌切开术和乳头球囊扩张术取石困难的多发、巨大且胆管扩张的胆管结石患者。②操作:乳头括约肌切开后行EPLBD能够提高首次取石成功率,降低机械碎石的应用。扩张球囊直径的选择应参照胆总管远端直径和胆管结石的短径。③特殊病例:EPLBD可应用于憩室旁乳头和外科手术后解剖改变患者。④操作相关不良事件:EPLBD相关早期不良事件发生率为0%~22.5%,包括出血、穿孔、胰腺炎和胆管炎。⑤治疗结果:对于胆总管结石患者,EPLBD的首次治疗取石成功率为80.9%~89%,最终的完全清除率为95.2%~100%。EPLBD术后胆管结石复发率为4.4%~14.5%。⑥术后随访观察:迟发性不良事件发生率为0%~10%,包括胆管结石复发、胆管炎和胆囊炎。

关键词: 球囊扩张术;指南;胰胆管造影术, , 内窥镜逆行

Abstract: Japan Gastroenterological Endoscopy Society has developed the ‘EPLBD Clinical Practice Guidelines’ as fundamental guidelines based on new scientific techniques. EPLBD is a treatment  method that has recently become widely used for choledocolithiasis. The evidence level in this field  is usually low, and in many instances, the recommendation grading has to be determined on the  basis of expert consensus. At this point, the guidelines are divided into the following six sections  according to the ‘EST Clinical Practice Guidelines’: ① Indications.EPLBD is indicated for large and multiple stones with bile duct dilatation that  are difficult to treat by EST and EPBD alone. ② Procedures. EPLBD following EST improves the stone removal rate in the first session, and it  might reduce the frequency of mechanical lithotripsy usage. The distal bile duct diameter and the short diameter of the stone are taken into  consideration when selecting the balloon diameter. ③Special cases. In patients with periampullary diverticulum, EPLBD can be performed. EPLBD also can be performed in patients with surgically altered anatomy. ④ Procedurerelated adverse events. The incidence of early adverse events caused by EPLBD is in the range of 0%22.5%, including bleeding, perforation, pancreatitis, and cholangitis.  ⑤Treatment outcomes. The rate of stone removal in EPLBD for gallstones of the common bile duct is from  80.9% to 89% for the initial treatment and ultimately from 95.2% to 100% for the complete stone  removal.The recurrent rate of bile duct stone after EPLBD is 4.4% to 14.5%.  ⑥Postoperative follow up  observation.Delayed adverse events other than recurrent stones of the common bile duct  have an incidence of 0% to 10% and include cholecystitis and cholangitis.

Key words: balloon dilation, guidebooks, cholangiopancreatography, endoscopic retrograde