关键词: 卒中, 阿替普酶静脉溶栓, 出血

Abstract: Objective  To retrospectively investigate the hemorrhage complications within 24 hours after intravenous thrombolysis of atropase in acute ischemic stroke (AIS). Methods  The data of  200 AIS patients treated by intravenous thrombolysis of atropase were collected, including age, sex, past medical history, bad hobby,  blood sugar, blood pressure, blood fat, liver and kidney function, platelet count, coagulation functionand so on. Bleeding complications and related risk factors were analyzed after intravenous thrombolytic therapy. Results  Systematic and intracranial hemorrhage occurred in 41 of 200 patients with thrombolysis,  with a bleeding rate of 20.5%(41/200) and a cerebral hemorrhage conversion rate of only 1.5%(3/200),  There were 21 cases of gingival bleeding, 9 cases of tongue bleeding,  2 cases of tongue and gingival bleeding, 1 case of subcutaneous bleeding, 3 cases of gastrointestinal bleeding, 1 case of urinary tract bleeding, 2 cases of intrainfarction focus bleeding, 1 case of tongue and intrainfarction focus bleeding,  and 1 case of intraventricular hemorrhage. And no severely disabled or fatal case caused by bleeding was found. Multivariate regression analysis showed that atrial fibrillation was an independent risk factor for bleeding after thrombolysis(P<0.05). Conclusion  The bleeding conversion rate of intravenous thrombolysis of atropase is very low,  and atrial fibrillation is an independent risk factor for bleeding after thrombolysis. Intravenous thrombolysis of atropase is effective and safe for acute cerebral infarction,  but the treatment should be individualized.

Key words: stroke, alteplase intravenous thrombolysis; , bleeding