Abstract:

Objective  To investigate the influence of the Wnt inhibitor XAV939 on the proliferation and apoptosis of small cell lung cancer (SCLC) H446 cells. Methods  MTT assays was used to detect the growth inhibition rate of cells in each group and to explore the optimized drug concentration. Flow cytometry was used to detect the impact of the XAV939 effects on cell apoptosis. Results  The XAV939 inhibited the growth of H446 in a dosedependent manner (P<0.01)， but cisplatin inhibited the growth of H446 in a time and dosedependent manner (P<0.01). The combination of both drugs inhibited the growth of H446 more significantly. In addition， the percentage of apoptosis of H446 cells increased with the increased concentration of XAV939(P<0.05). Conclusion  The data indicated that the XAV939 inhibited the growth of SCLC H446 cells by Wntinduced cell apoptosis， and it may become a helpful treatment tool for SCLC.

Key words: small cell lung carcinoma, cell apoptosis；wnt signaling pathway, XAV939