Abstract: ObjectiveTo explore the change of newborn umbilical arterial blood serum amyloid A (SAA) and interleukin6 (IL6). MethodsA total of 86 cases of newborn umbilical arterial blood were collected between April 2015 and March 2016， including 13 cases of extremely critical group， 23 cases of critical group， 20 cases of noncritical group and 30 cases of normal group. The levels of serum SAA and IL6 were determined by ELISA and compared between four groups. The receiveroperating characteristic curve(ROC) was adopted to define SAA and IL6 in the diagnosis of the critical point of tangency of a newborn. The judgement of sensitivity and specificity were calculated in the critically ill newborns. ResultsThe levels of serum SAA and IL6 in disease groups were significantly higher than those in normal group (P<0.05). The levels of SAA and IL6 were positively correlated with the degree of critically illness(P<0.05). The areas of SAA and IL6 in the diagnosis of neonatal critical illness under ROC curve were 0.925(95%CI) and 0.945(95%CI)， respectively. The sensitivity and specificity of SAA were 83.9% and 96.7%， respectively; the sensitivity and specificity of IL6   76.8% and 96.7%， respectively.ConclusionThe levels of SAA and IL6 can reflect the severity of illness and better identify the critical neonates in a timely manner. Meanwhile， the SAA and IL6 have higher sensitivity and specificity and can be used in neonatal critical illness assessment.

Key words: intensive care, neonatal, serum amyloid A protein, interleukin6