Abstract: ObjectiveTo investigate the relationship of serum omentin1 and gestational diabetes mellitus (GDM). MethodsSerum omentin1， fasting plasma glucose (FPG) and fasting insulin (FINS) were tested in 85 cases of GDM with prepregnancy obesity， 85 cases of GDM with normal pregnancy and 85 cases of NGT. The resistance of insulin (HOMA IR) was calculated and statistically analyzed. Results① The FPG， FINS and HOMAIR in GDM group were significantly higher than NGT group， and the last two appeared: obesity GDM > nonobese GDM>NGT group (P<0.05); ② Serum omentin1 in  GDM group was obviously lower than NGT group， obesity GDM<non obese GDM<NGT group (P<0.05); ③ Correlation analysis: serum omentin1 was significantly negative correlation with BMI， FPG， FINS and HOMAIR; ④ The multiple regression analysis, pregnancy obesity GDM group: omentin1=484.1265.015BMI7.016FPG13.224FINS; GDM with normal pregnancy group: omentin1=497.0084.092BMI6.079FPG11.258FINS.ConclusionSerum omentin1 is associated with GDM closely，which can reflect degrees of sugar， lipid metabolic disorder and insulin resistance in pregnant women， may be involved in the occurrence and development of GDM.

Key words: adipokines, omentin1, diabetes, gestational