Abstract: ObjectiveTo investigate  the diagnostic value of autofluorescence bronchoscopy in lung diseases. MethodsA total of 168 patients were detected by using both white light bronchoscopy(WLB)  mode and autofluorescence bronchoscopy(WFB) mode of Pentax SAFE3000 bronchoscopy. Biopsies of the positive regions were taken for pathologic examination. ResultsTotally 128 of 168 patients had abnormal changes in WLB mode， 144 patients had abnormal changes in AFB mode. The pathologic diagnoses for 168 biopsy specimens were as follows: bronchogenic carcinoma in 97 cases， pulmonary inflammation in 40 cases， tuberculosis in 19 cases and  pulmonary sarcoidosis in 12 cases. The respective sensitivities of WLB and AFB were 81.44% and 95.88% (χ2=12.071，P=0.000) in bronchogenic carcinoma， and the respective specificities  did not show significant difference (χ2=2.250，P=0.134). The differences of sensitivities and specificities of  WLB and AFB in pulmonary inflammation， tuberculosis， and pulmonary sarcoidosis were not statistically significant (P>0.05). ConclusionThe value of WLB and AFB in the diagnosis of lung inflammation， tuberculosis and sarcoidosis is equivalent. The sensitivity of AFB in diagnosing lung cancer was higher than WLB.

Key words: bronchoscopes, lung disease, diagnosis