Application value of cerebrospinal fluid and serum PCT and CRP in diagnosis of central nervous system infection

doi:10.3969/j.issn.1004-583X.2021.08.006

Abstract

Abstract:

Objective To investigate the application value of cerebrospinal fluid and serum procalcitonin(PCT), C-reactive protein(CRP) in diagnosis of infection of the central nervous system(ICNS). Methods Totally 72 ICNS patients admitted to our hospital from Jan 2016 to Dec 2020 were selected as observation group, they were divided into pyogenic infection subgroup (44 cases) and viral infection subgroup (28 cases) by infection type; in addition, 80 no-ICNS patients were regarded as control group. Cerebrospinal fluid and serum CRP, PCT level between groups were counted.Results Cerebrospinal fluid and serum PCT, CRP were higher in observation group than in control group (P<0.05); PCT, CRP in serum and cerebrospinal fluid were higher in pyogenic infection subgroup than in viral infection subgroup (P<0.05); ROC curve analysis showed that important factors for predicting ICNS were PCT (AUC=0.890), CRP (AUC=0.823) of cerebrospinal fluid, as well as serum PCT (AUC=0.793), CRP (AUC=0.729)(P<0.01). Conclusion Cerebrospinal fluid and serum PCT, CRP can be used as an indicator for diagnosis of ICNS, of which PCT of cerebrospinal fluid has a higher diagnostic efficiency.

Key words: central nervous system infections, diagnosis, inflammatory cytokines

CLC Number:

R742.89

Li Dan, Hua Guohui. Application value of cerebrospinal fluid and serum PCT and CRP in diagnosis of central nervous system infection[J]. Clinical Focus, 2021, 36(8): 704-707.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.08.006

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I8/704

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References 20

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组别	例数	性别[例(%)]		年龄 (岁)	原发病[例(%)]		APACHEII 评分(分)	SOFA评分 (分)
组别	例数	男	女	年龄 (岁)	颅脑外伤	高血压性脑出血	APACHEII 评分(分)	SOFA评分 (分)
观察组	72	43(59.72)	29(40.28)	44.82±11.38	24(33.33)	48(66.67)	14.96±3.46	11.37±1.92
对照组	80	48(60.00)	32(40.00)	45.64±12.84	27(33.75)	53(66.25)	14.72±3.22	11.64±1.85
t值/χ²值		0.001		0.415	0.003		0.443	0.882
P值		0.972		0.679	0.957		0.658	0.379

组别	例数	性别[例(%)]		年龄 (岁)	原发病[例(%)]		APACHEII 评分(分)	SOFA评分 (分)
组别	例数	男	女	年龄 (岁)	颅脑外伤	高血压性脑出血	APACHEII 评分(分)	SOFA评分 (分)
观察组	72	43(59.72)	29(40.28)	44.82±11.38	24(33.33)	48(66.67)	14.96±3.46	11.37±1.92
对照组	80	48(60.00)	32(40.00)	45.64±12.84	27(33.75)	53(66.25)	14.72±3.22	11.64±1.85
t值/χ²值		0.001		0.415	0.003		0.443	0.882
P值		0.972		0.679	0.957		0.658	0.379

组别	例数	PCT(μg/L)		CRP(mg/L)
组别	例数	脑脊液	血清	脑脊液	血清
观察组	72	2.13±1.03	1.80±0.84	21.42±7.67	18.34±5.85
对照组	80	0.86±0.47	0.73±0.61	9.47±4.24	8.04±1.23
t值		9.941	9.048	12.043	15.380
P值		<0.01	<0.01	<0.01	<0.01

组别	例数	PCT(μg/L)		CRP(mg/L)
组别	例数	脑脊液	血清	脑脊液	血清
观察组	72	2.13±1.03	1.80±0.84	21.42±7.67	18.34±5.85
对照组	80	0.86±0.47	0.73±0.61	9.47±4.24	8.04±1.23
t值		9.941	9.048	12.043	15.380
P值		<0.01	<0.01	<0.01	<0.01

组别	例数	PCT(μg/L)		CRP(mg/L)
组别	例数	脑脊液	血清	脑脊液	血清
化脓性感染亚组	44	2.85±1.14	2.78±0.96	25.92±8.13	24.37±6.22
病毒性感染亚组	28	1.38±1.21	1.21±0.94	16.75±7.33	15.21±5.73
t值		5.173	6.819	4.844	6.278
P值		<0.01	<0.01	<0.01	<0.01