Abstract: With the fast development of endoscopic technique and the acknowledge about the  gastrointestinal neoplasms， the detection rate of early gastrointestinal carcinoma in China shows an increasing trend.  Endoscopic submucosal dissection(ESD) is a kind of minimal invasive therapy to early gastrointestinal carcinoma and precancerous lesions. By ESD，  the lesions can be resected completely and the gastrointestinal carcinoma can be cured. We discussed  the cooperation and the nursing method during ESD for early gastrointestinal carcinoma and precancerous lesions. The goal is to increase the professional level of endoscopy nursing intervention.

Key words: digestive system neoplasms, endoscopic submucosal dissection, nursing care