Abstract: Hepatokines is a protein excreted into the blood only or mainly by the liver that directly affects glycolipid metabolism. It can accelerate and delay the occurrence and development of diabetic nephropathy,  especially in the pathophysiological mechanism of insulin resistance.It directly affects lipid metabolism. Our understanding towards them is of great significance for the early diagnosis and treatment of diabetic nephropathy. In this paper, recent advances on the pathogenesis of hepatokines in diabetic nephropathy are summarized.

Key words: hepatokines, diabetic nephropathy, , insulin resistance, , pathogenesis