Abstract: Objective  To explore the role of Cytokeratin 7（CK7 ）in the pathological diagnosis of liver cirrhosis.Methods  A retrospective analysis was performed on the liver pathology of the Department of Pathology, Beijing You'an Hospital, Capital Medical University, from January 2014 to May 2018. This study included 802 cases, 563 males and 239 females, with an average age of (51±11) years. The positive expression ratio of CK7 immunohistochemical staining in liver tissue pathology was analyzed when different diseases were complicated by cirrhosis. Results   The proportion of males with negative expression of CK7 in liver tissue was larger, while the proportion of females with positive expression of CK7 in liver tissue was higher than that of CK7 negative patients. The average age of CK7 immunohistochemical staining in liver cirrhosis liver tissue was larger than that of CK7 positive cases. The positive rate of CK7 immunohistochemical staining in nonviral cirrhosis liver tissue was higher than that in viral cirrhosis group. Compared with chronic hepatitis B cirrhosis and autoimmune hepatitis cirrhosis,  the positive rate of CK7 in liver tissue of patients with PBC cirrhosis was significantly increased. Conclusion  CK7 immunohistochemical staining has a certain guiding value in distinguishing between viral and nonviral cirrhosis. CK7 plays an important role in the identification of PBC and autoimmune hepatitis and hepatitis B cirrhosis.

Key words: liver cirrhosis;liver pathology, hepatitis, , viral, , human, cholangitis, hepatitis, , autoimmune