Abstract: Objective  To investigate the effect of nutritional status on chemotherapyinduced nausea and vomiting by cisplatinbased chemotherapy in patients with lung cancer. Methods  A total of 200 patients with lung cancer who received cisplatin chemotherapy in the First People's Hospital of Changzhou was selected, and ondansetron was used as antiemetic drug. All patients  are divided into a malnutrition group and a nonmalnutrition group according to PGSGAscore, and the clinical data, nutritionrelated indicators, and CINV were analysed. Nutritional intervention was performed on malnourished patients, and the duration of CINV before and after nutritional intervention was compared. Results  Among  the 200 patients included, the PGSGA score was ≥4 points in 122 cases, which indicated  that 61% of  the 200 patients had malnutrition. There were no significant differences in clinical data between the two groups in terms of gender, age, tumor type, tumor stage, and chemotherapy regimen (P>0.05). Multivariate regression analysis showed that malnutrition was an independent risk factor for CINV(P<0.01). After nutritional intervention in patients with malnutrition, the duration of nausea and vomiting was improved (P<0.01). Conclusion  Malnutritionisan is independent risk factor for CINV, and nutritional intervention can improve the duration of CINV.

Key words: lung neoplasms;nutritional status, cisplatin, chemotherapyinduced nausea and vomiting