Abstract: Objective  To adopt intraperitoneal  administration and observe the control group(Cisplatin) and combination group(endostatin combined with cisplatin)in order to see the effects on elderly patients with malignant ascites in clinical efficacy,  the improvement of life quality and immunity.Methods  Totally sixtyfour elderly patients diagnosed with malignant ascites were collected. And they were divided into control group and combination group. Patients in control group were given 30 mg of cisplatin  by intraperitoneal  administration on day 1,  day 4,  day 7,  respectively. And one cycle of treatment was  21 days. Patients in combination group were given 30 mg of cisplatin  and 45 mg of  endostatin (Endostar)  by intraperitoneal administrationon day 1,  day 4,  day 7,  respectively. And one course of treatment was 21 days. All  patients in two groups were treated for two cycles. The efficacy evaluation criteria(RECIST)was used to evaluate clinical efficacy of  two groups,  and the side effects were evaluated by NCI. The improvement of anxiety and depression was evaluated by psychological questionnaire,  and the level of CD4/CD8 was monitored before and after treatment.Results  The efficacy of  experimental group was higher than that of  control group,  which significantly improved the anxiety and depression of the patients; the CD4/CD8 of  experimental  group was not significantly lower than that of  control group. Conclusion  Endostar  combined with cisplatin can improve the remission rate of ascites without obvious side effects,  and they can also improve the state of anxiety and depression without reducing the immunity of patients.

Key words: ascites；endostatin; , cisplatin;  , intraperitoneal administration, aged