Early application of low molecular heparin in treatment of senile severe sepsis

doi:10.3969/j.issn.1004-583X.2018.02.016

Abstract

Abstract: Objective To observe the effect and mechanism of early application of low molecular heparin in treatment of senile severe sepsis. Methods Thirtytwo cases of elderly patients with severe sepsis were randomly divided into experimental group and control group， control group given conventional treatment， treatment group on the basis of conventional treatment to low molecular heparin. Before and after treatment， APACHE Ⅱ score， SOFA score and the incidence of MODS， 28 days in hospital mortality and plasma thromboplastin， Ddimer， blood fibrinogen (FIB)， platelets and coagulation function index and serum levels of interleukin6(IL6)， tumor necrosis factor alpha were observed in two groups. Results After treatment， the APACHE grade and SOFA and the serum level of IL6 in treatment group were significantly lower than those in control group. Conclusion Early application of low molecular heparin can improve the prognosis of elderly patients with severe sepsis by improving coagulation function and reducing inflammatory response.

Key words: enoxaparin, sepsis, aged

Ge Chunli1， Song Rong2. Early application of low molecular heparin in treatment of senile severe sepsis[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2018.02.016.

Add to citation manager EndNote|Ris|BibTeX

URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2018.02.016

https://huicui.hebmu.edu.cn/EN/Y2018/V33/I2/153

[1]	Huang Saihu, Long Zhongjie, Dong Xingqiang, Meng Xiangying, Wu Shuiyan, Bai Zhenjiang. Pathogen and clinical characteristics of children with hematologic neoplasms complicated with sepsis [J]. Clinical Focus, 2024, 39(1): 38-42.
[2]	Tang Aijun, Wang Liwei. Predictive values of platelet count and coagulation index in the 28-day survival of sepsis patients [J]. Clinical Focus, 2023, 38(3): 250-254.
[3]	Chai Chunyan, Wang ting. Clinical analysis of three elderly patients with hypercalcemia and literature review [J]. Clinical Focus, 2023, 38(2): 166-169.
[4]	Zhou Lijuan, Zhu Pengwei, Cao Mei, Cheng Zhenmei, Wu Qiaowei, Li Yong. Correlation of serum ferritin, erythrocyte parameters and D-dimer with sepsis in children [J]. Clinical Focus, 2023, 38(1): 60-63.
[5]	Zhou Bin, Zeng Cizheng, Huang Yuge, Zhong Mianling, Wu Jiayuan. Effect of pSOFA score combined with C-reactive protein and procalcitonin in prognosis assessment of sepsis children [J]. Clinical Focus, 2022, 37(7): 616-622.
[6]	Zhang Mengyuan, Zhu Yong. Predictive value of procalcitonin clearance and SOFA score on the prognosis of patients with severe sepsis [J]. Clinical Focus, 2022, 37(3): 225-229.
[7]	Xiao Liuniu, Zhong Yanxia, Li Shusheng. Effect of extracorporeal hemopurification for clinical prognosis and cytokine levels of septic: A meta-analysis [J]. Clinical Focus, 2022, 37(1): 5-13.
[8]	Hou Wei, Zhang Lijun, Zhang Man, Wang Yakun, Jia Meixuan, Tian Liyuan. Clinical analysis in 84 children with the sepsis of non-elevated peripheral blood leukocytes [J]. Clinical Focus, 2021, 36(9): 799-802.
[9]	Zhang Yuan, Huang Tao, Wang Baoping. Clinical significance of blood lactic acid assisted APACHEⅡ in judging prognosis of elderly SI patients in ICU [J]. Clinical Focus, 2021, 36(7): 604-607.
[10]	Eamran Hossain, Tian Ya, Chen Yuan, Zhang Shaodan, Zhang Huifeng. IPEX syndrome concurrent with gut-origin sepsis: A child patient report and literature review [J]. Clinical Focus, 2021, 36(5): 453-457.
[11]	Liu Yuanliang, Li Biao, Jiang Zuofeng, Zhu Youfeng, Zhang Shaoheng, Wang Yarong, Li Rongseng, Li Li. Efficacy and safety of half-dose versus standard-dose of tirofiban for percutaneous coronary intervention in elderly Chinese patients with acute coronary syndrome: a meta-analysis [J]. Clinical Focus, 2021, 36(11): 965-971.
[12]	Liu Qiaoxue, Wei Hui. Standardized treatment of acute myeloid leukemia [J]. Clinical Focus, 2021, 36(10): 880-883.
[13]	Zhang Xinhui, Gu Yumeng, Wang Zhongyan, Wang Donglai, Xia Xiaoshuang, Wang Lin, Liu Xia. Status investigation of chronic comorbidity status in elderly at tertiary hospitals and community hospitals [J]. Clinical Focus, 2021, 36(1): 39-43.
[14]	Lu Yalei1, Song Lina2, Shan Yujie1, Zhang Xiaolin3a, Jia Jinhai3b. Effect of endostatin combined with cisplatin on elderly cancer patients with malignant ascites [J]. Clinical Focus, 2020, 35(2): 162-165.
[15]	Luo Di, Wang Xiaofei, Wang Lei. Difference between central arterial blood pressure and brachial blood pressure and influencing factors in patients with coronary artery disease [J]. Clinical Focus, 2020, 35(12): 1089-1092.

Early application of low molecular heparin in treatment of senile severe sepsis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments