Correlation of serum ferritin, erythrocyte parameters and D-dimer with sepsis in children

doi:10.3969/j.issn.1004-583X.2023.01.008

Abstract

Abstract:

Objective To investigate the evaluation value of erythrocyte parameters, D-dimer (DD) and serum ferritin (SF) on the state and prognosis of sepsis in children, and to explore their relationship. Methods We carried out a retrospective analysis on 173 children with sepsis who visited Wuxi Children's Hospital of Jiangsu Province from July 2015 to June 2022, including Hemoglobin(Hb), red blood cell distribution width(RDW), DD, SF, the severity of illness and the prognosis, and explored its interrelation and related mechanism. Results There were 82 cases in non-severe group, 64 cases in severe group and 27 cases in extremely severe group. Hb was decreased and RDW, DD and SF were increased gradually with increased severity of illness, with statistically significant differences ( $P$ <0.01). Hb was negatively correlated with RDW and DD ( $r$ =-0.527 and -0.629, $P$ <0.05). RDW was positively correlated with DD( $r$ =0.587, $P$ <0.05). SF was negatively correlated with Hb( $r$ =-7.324, $P$ <0.05). SF was positively correlated with RDW and DD ( $r$ =0.513 and 0.697, $P$ <0.05). Among 173 children with sepsis, there were 21cases in death group and 152 cases in survival group. Hb in death group was significantly lower than that in survival group and RDW, DD and SF in death group were significantly higher than those in survival group ( $P$ <0.01). There were 124 children in sepsis group and 49 children in septic shock group. Hb in sepsis group was significantly higher than that in septic shock group, and RDW, and DD and SF were significantly lower than those in septic shock group ( $P$ <0.01). Conclusion Hb, RDW, DD and SF have some evaluation value on the state and prognosis of sepsis in children, and the erythrocytes damaged by microcirculation disturbance may be the main source of SF.

Key words: sepsis, red cell parameters, D-dimer, serum ferritin

CLC Number:

R725

Zhou Lijuan, Zhu Pengwei, Cao Mei, Cheng Zhenmei, Wu Qiaowei, Li Yong. Correlation of serum ferritin, erythrocyte parameters and D-dimer with sepsis in children[J]. Clinical Focus, 2023, 38(1): 60-63.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.01.008

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I1/60

Figures/Tables 3

Tab.1 Comparison of indicators on the first day in three groups( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
非危重组	82	104.43±11.25	12.51±2.12	2.125±0.124	182.47±21.26
危重组	64	96.27±3.13	14.23±1.37	4.232±0.093	329.13±37.28
极危重组	27	87.46±2.36	16.86±2.59	6.072±0.186	543.75±50.32
$F$ 值		11.47	19.31	24.17	27.69
$P$ 值		0.00	0.00	0.00	0.00

Tab.1 Comparison of indicators on the first day in three groups( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
非危重组	82	104.43±11.25	12.51±2.12	2.125±0.124	182.47±21.26
危重组	64	96.27±3.13	14.23±1.37	4.232±0.093	329.13±37.28
极危重组	27	87.46±2.36	16.86±2.59	6.072±0.186	543.75±50.32
$F$ 值		11.47	19.31	24.17	27.69
$P$ 值		0.00	0.00	0.00	0.00

Tab.2 Comparison of indicators between death group and survival group( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
死亡组	21	78.13±5.24	17.19±2.53	5.482±0.812	559.47±42.11
存活组	152	95.47±2.18	13.72±1.66	2.273±0.013	262.51±31.63
$t$ 值		-17.22	18.52	20.03	16.08
$P$ 值		0.00	0.00	0.00	0.00

Tab.2 Comparison of indicators between death group and survival group( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
死亡组	21	78.13±5.24	17.19±2.53	5.482±0.812	559.47±42.11
存活组	152	95.47±2.18	13.72±1.66	2.273±0.013	262.51±31.63
$t$ 值		-17.22	18.52	20.03	16.08
$P$ 值		0.00	0.00	0.00	0.00

Tab.3 Comparison of indicators between sepsis group and septic shock group( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
脓毒症组	124	102.23±4.16	13.41±1.82	2.983±0.018	231.85±42.86
脓毒性休克组	49	89.41±2.95	16.88±3.01	5.972±0.973	513.97±69.43
$t$ 值		15.43	-9.58	-13.97	-19.55
$P$ 值		0.00	0.00	0.00	0.00

Tab.3 Comparison of indicators between sepsis group and septic shock group( x -±s)

组别	例数	Hb(g/L)	RDW(%)	DD(mg/L)	SF(μg/L)
脓毒症组	124	102.23±4.16	13.41±1.82	2.983±0.018	231.85±42.86
脓毒性休克组	49	89.41±2.95	16.88±3.01	5.972±0.973	513.97±69.43
$t$ 值		15.43	-9.58	-13.97	-19.55
$P$ 值		0.00	0.00	0.00	0.00

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