Abstract: Objective  To explore the clinical efficacy of plasma  diafiltration（PDF） in treatment of hepatic failure with sepsis. Methods  Clinical data of 31 patients with hepatic failure and sepsis were retrospectively analyzed. The recruited patients accepted comprehensive medical treatments such as PDF, antiinfection and others.Changes in clinical symptoms and physical signs  were observed  before and after treatment. The levels of coagulation function (prothrombin activity and fibrinogen), biochemical indicators (transaminase, total bilirubin, blood creatinine and ions) and endstage liver disease model score  were investigated  before and after treatment, and the changes of primogen, interleukin6, Creactive protein, blood routine, lactic acid, and sequential organ failure scores were compared were evaluated  before and after PDF.Results  The clinical effective rate was 61.29%, and the adverse reaction was 8.21%. There were significant differences in PTA, fibrinogen, TBIL, AST, Na+, K+, PCT, IL6, CRP, WBC, lactic acid, SOFA and MELD scores before and after PDF treatment (P<0.05). Conclusion  PDF can significantly improve the coagulation function and liver function of patients with hepatic failure and sepsis, and can eliminate inflammatory factors and effectively relieve the disease with combined treatment.

Key words: liver failure, sepsis, plasma , diafiltration; , clinical efficacy