Abstract: Objective   To investigate the efficacy and safety of double plasma absorption(DPMAS) combined with plasma exchange (PE) in the treatment of acuteonchronic liver failure.Methods   Totally 69 cases of acuteonchronic liver failure treated with artificial liver treatment  were  retrospectively analyzed since January 2016  to December 2018. The patients were divided into combination group with 32 patients(DPMAS combined with PE)and control group with 37 patients(PE alone). Changes in laboratory tests,  clinical effection and adverse reaction before  and after different modes of treatment were compared. Results  The two groups showed no significant differences in the effectiveness and 12week survival rate. After treatment,  the levels of TBil, ALB and TBA in combination group were significantly improved than those of control group. There were significant  differences in liver function and blood coagulation function before and after treatment between two groups. Conclusion  The treatment of DPMAS  combined with PE  can improve liver  function and blood coagulation function  in comparison with simple PE.

Key words: liver failure, liver, artificial, plasma exchange;double plasma absorption