Sepsisinduced acute kidney injury: a disease of the microcirculation

doi:10.3969/j.issn.1004-583X.2019.07.004

Clinical Focus

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Sepsisinduced acute kidney injury: a disease of the microcirculation

1.Departmentof Critical Care Medicine, the Fourth Hospital of Hebei Medical, Shijiazhunag 050011, China;
2.Departmentof Critical Care Medicine, Peking Union Medical College Hospital, Beijing 100730, China;
3. Department of Critical Care Medicine, the First Hospital of Tsinghua University, Beijing 100010, China;
4.Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China;
5.Department of Intensive Care Unit, Xiangya Hospital Central South University, Changsha 410008, China;
6.Department of Critical Care Medicine, Beijing Tongren Hospital, Beijing 100730, China;
7.Department of Critical Care Medicine, Ruijin Hospital Afiliated to Shanghai Jiao Tong University School
of Medicine, Shanghai 200025, China; 8.Department of Critical Care Medicine,
the First Hospital of China Medical University, Shenyang 110001,

Online:2019-07-20 Published:2019-08-24
Contact: Coresponding author: Hu Zhenjie, Email: syicu@vip.sina.com

Abstract

Abstract: The renal hemodynamics in sepsis induced acute kidney injury (AKI) is characterized by renal macro and microcirculation separation. In such case, renal blood flow is normal or even enhanced, while the renal microcirculation is in a state of ischemia and hypoxia because of the intrarenal blood shunt, heterogeneity, stasis and obstruction. This phenomenon suggests that septic AKI belongs to microcirculation disease, and “microcirculation perfusion guided” strategy should be a therapeutic goal in future.

Key words: sepsis, acute kidney injury

Liu Lixia1, Wang Xiaoting2, Chao Yangong3, Zhang Hongmin2, Wu Jun4, Yin Wanhong5, Zhang Lina6,He Wei7, Zhu Ran8, Ding Xin2, Zhang Qian1, Hu Zhenjie1, Chinese Critical Ultrasound Study Group . Sepsisinduced acute kidney injury: a disease of the microcirculation[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.07.004.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2019.07.004

https://huicui.hebmu.edu.cn/EN/Y2019/V34/I7/595

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Sepsisinduced acute kidney injury: a disease of the microcirculation

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