Abstract: Objective   To investigate the expression and significance of endothelial cell specific molecule1 (ESM1) in serum of nonmyocardial infarction patients with coronary heart disease (CHD). Methods   Forty patients of CHD with nonmyocardial infarction were selected as observation group, and 40 patients with nonCHD  as control group. The serum levels of ESM1 and inflammatory factors related to CHD  in all patients. The relationship between ESM1 content and inflammatory factors with CHD was explored. Results  There were significant differences in the levels of ESM1 and inflammatory factors related to CHD between two groups (P<0.001). Multiple linear regression analysis showed that ESM1 was positively correlated with inflammatory factors VCAM1, TNFα and IL8 (P<0.001). Conclusion  The elevated levels of ESM1 and inflammatory factors in serum of nonmyocardial infarction patients with CHD play an important role in the occurrence of CHD.

Key words: coronary , artery disease, endothelial growth factors, cytokines