Abstract: Objective  To observe the clinical value of galectin3 (Gal3),  soluble suppression of tumorigenicity2 (sST2),  and brain natriuretic peptide (BNP) in heart failure with preserved ejection fraction (HfpEF) in predicting major cardiovascular adverse events(MACE).Methods  A total of 126 patients diagnosed as HfpEF and treated in our hospital were selected as HfpEF group,  and 60 healthy people who underwent physical examination in our hospital during the same period were selected as healthy control group. The serum Gal3,  sST2 and BNP levels were measured by enzymelinked immunosorbent assay (ELISA). The serum Gal3,  sST2,  BNP,  LAVI,  and LVEF were compared between two groups,  the relation among the levels of the items,  cardiac function classification and MACE,  and the sensitivity and specificity of serum Gal3,  sST2 and BNP  in predicting MACE    were also observed.Results  The levels of serum Gal3,  sST2,  BNP and LAVI in HfpEF group were significantly higher than those in healthy control group (P<0.01), and the levels increased as the rise of heart failure classification(P<0.01). The serum Gal3,  sST2,  BNP,  and LAVI in MACE group in patients with HfpEF were significantly higher than those in nonMACE group (P<0.01). The serum Gal3,  sST2 and BNP in patients with HFpEF had higher sensitivity and specificity in predicting MACE. Combined detection (Gal3+sST2+BNP) in predicting MACE had higher diagnostic efficiency,  its sensitivity and specificity were 96.4% and 91.8%,  respecticely. And its area under the curve (AUC) was significantly higher than Gal3 (Z=3.328, P<0.01),  sST2(Z=2.316, P<0.01) and BNP (Z=2.985, P<0.01). Conclusion  The serum Gal3, sST2 and BNP levels are related to the severity of HfpEF, and have important clinical value in predicting MACE.

Key words: heart failure, , congestive;galectin3, brain natriuretic peptide;stroke volume