Abstract: Objective  To investigate the clinical characteristics and influencing factors of  mycoplasma pneumoniae (MP) infection with EpsteinBarr (EB) virus in children. Methods  The research subjects of this experiment included 87 cases of hospitalized children with EB virus complicated with MP infection as observation group. And 70 patients with simple MP infection at the same time were selected as control group. The differences in general data, laboratory results and clinical conditions between two groups were compared and analyzed. Results  EB virus combined with MP infection was mostly seen in preschool children and the gender difference was not obvious. Blood routine examination showed that white blood cells of children with MP and EB virus infection were significantly higher than thoseof children with MP infection alone (P<0.05).  Serum biochemistry showed transient elevation of AST, ALT and CKMB. Imageological examination suggested that the degree of pulmonary substantive lesion was higher in children with concurrent  infection and pleural effusion was more likely to happen. The clinical features of children with concurrent infection showed that lymph nodes were more prone to swelling, and the extension of fever duration. Conclusion  Compared with MP infection alone，the clinical manifestation of EB virus combined with MP infection is more serious and often involves multiple organs.

Key words: mycoplasma pneumoniae, epsteinbarr virus, child, influencing factor