Abstract: Objective   To investigate the relationship between the levels of serum cystatin C (CysC), fibrinogen (FBG) and Creactive protein (CRP) and the occurrence and rupture of intracranial aneurysms.Methods   A total of 100 patients with intracranial aneurysms were divided into the ruptured group (n=54) and the unruptured group (n=46), and 50 healthy people were selected as the control group. Blood and cerebrospinal fluid samples were collected and the levels of serum CysC, FBG and CRP were measured. Results   Among patients with intracranial aneurysms, the proportion of drinking, smoking, hypertension and atherosclerosis was significantly higher than that of the control group, and the proportion of age ≥60 years old, male, drinking, smoking, diabetes, hypertension and atherosclerosis in the ruptured group were higher(P<0.05). Compared with the control group, the levels of CysC, FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms were significantly increased(P<0.05). Conclusion  The levels of CysC, FBG and CRP in the blood and cerebrospinal fluid of patients with intracranial aneurysms are increased abnormally, and the levels of CysC, FBG and CRP are related to the rupture of intracranial aneurysms.

Key words: intracranial aneurysm, serum cystatin C, fibrinogen, Creactive protein