Abstract: Objective   To analyze the antibiotic resistance characteristics of  Helicobacter pylori(H.pylori) in Shenzhen,  and the eradication rate of it  based on the results of antibiotic resistance. Methods   Patients undergoing gastroscopy with initial treatment of  13C  urea breath test (13CUBT) positive in Shenzhen from January 2017 to December 2018 were collected. H.pylori culture and antimicrobial susceptibility testing  were carried out to analyze the antibiotic resistance characteristics. H.pyloriwas cured according to the drug susceptibility. The eradication rate of H.pyloribased on the antimicrobial susceptibility testing and resistance background  was analyzed.Results   A total of 688 H.pyloricultures were completed from January 2017 to December 2018,  and the positive rate of culture was 76.9%. The antimicrobial susceptibility testing showed the antibiotic resistance rates: 1.3% for amoxicillin,  34.0% for clarithromycin,  40.5% for levofloxacin,  and 90.4% for metronidazole. No resistance was observed for furazolidone and tetracycline hydrochloride. The resistance rate for multiple antibiotics was 56.1%. The eradication rate of patients with positive culture was 94.4% based on the results of antimicrobial susceptibility testing,  and that  of patients with negative culture was 85.4% according to the resistance background. Conclusion   Shenzhen sees  that the multiple antibiotics resistance rate for H.pyloriwas higher than 55%. The resistance rate of amoxicillin,  furazolidone and tetracycline was low,  and that of clarithromycin and  levofloxacin was relatively higher. And levofloxacin  had a higher resistance rate than clarithromycin. The eradication rate for H.pylori could be improved  according to the results of antimicrobial susceptibility testing and  the local antibiotic resistance background.

Key words: Helicobacter pylori, bacterial culture, antibiotic resistance, multicenter study