Abstract: ObjectiveTo investigate the association between TNFα 1031 T>C polymorphisms and helicobacter pylori(H.pylori) infection. MethodsPublished literatures within CNKI， VIP Database， Wanfang Database， PubMed， Embase， and the Cochrane Library were searched. Data were analyzed with the Stata12.0 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI).ResultsA total of ten studies involving 2 328 patients were included in this study. The results of metaanalysis showed that TNFα 1031 T>C polymorphisms was associated with decreasing H.plylori infection（TT vs CC，OR=0.61，95%CI=0.440.85，P=0.003; TT+CT vs CC，OR=0.61，95%CI=0.440.84，P=0.002）. However， there was no significant difference between allele model（T vs C， OR=0.92，95%CI=0.821.02，P=0.106） and recessive model（TT vs  CC+CT，OR=0.96，95%CI=0.841.09，P=0.504）.ConclusionTNFα 1031 T>C polymorphisms may be associated with a decreasing risk of H. pylori infection. Further studies with different ethnicities and larger sample size are required to validate the results.

Key words: helicobacter pylori, genetic predisposition to disease, tumor necrosis factor, polymorphisms