Abstract: Objective  To explore the risk factors forcomposite end point events in patients with coronavirus disease 2019 (COVID19). Methods  PubMed, EMbase, Web of Science, MedRxiv, CNKI, WanFang and VIP databases were searched to collect cohort,casecontrol and crosssectional studies on the risk factors for composite end point in patients with COVID19 from November 2019 to March 27, 2020. Composite end point events included the  admission to an intensive care unit (ICU)with the use of mechanical ventilation, or death. Metaanalysis was performed by using RevMan 5.3 and STATA 14 software. Results  A total of 8 studies involving 46 665 objects and 20 risk factors were included. The results of metaanalysis showed that: The older  males with history of hypertension, diabetes mellitus, chronic heart disease, cerebrovascular disease, tumor and smoking history, and whose CT showed bilateral lung involvement, as well as higher levels of alanine aminotransferase, glutamic oxalacetic aminotransferase,white blood cell count, neutrophils, creatinine, D dimer, prothrombin time and hypersensitive troponin I, may have higher risk of composite endpoint events. Patients with lower levels of albumin, platelet count, and lymphocyte count may have a higher risk of a composite endpoint events. Conclusion  The older patients  with preexisting medical history, the presence of heart, liver, kidney and other organ involvement, and whose  CT results suggest that bilateral lung involvement have a higher risk of composite endpoint events. Clinical attention should be paid to these patients and early intervention should be carried out.

Key words: coronavirus infections, coronavirus disease 2019, risk factor