Abstract:

Objective To investigate the correlation between hemoglobin (Hb) concentration and local control rate and long-term survival rate on esophageal cancer(EC) patients undergoing radiotherapy(RT). Methods Totally 88 EC patients admitted to our hospital from January 2016 to January 2017 were selected, RT was performing in all patients, therapeutic effect was observed and Hb concentration was measured before and after radiotherapy. Results After radiotherapy, local effective patients was 38 (43.18%) including 8 patients with complete remission(CR) and 30 patients with partial remission(PR); the rest were ineffective patients was 50 including 29 patients with stable disease(SD) and 21 patients with progressive disease(PD). In local effective patients, Hb concentration was (110.15±7.54) g/L, percentage of ratio > 1 (Hb post-RT/Hb bef-RT) was 73.68%, which were significantly higher than those in ineffective patients (P<0.05); percentage of lesion length >5 cm and tumor node metastasis(TNM) classification IV were 34.21% and 31.58%, which were significantly lower than those in ineffective patients (P<0.05); logistic regression analysis showed that influencing factors for local effective patients with EC were ratio>1 (Hb post-RT/Hb bef-RT), lesion length and TNM classification (OR=0.702, 2.330 and 2.729, P<0.05); the median survival time in the patients with ratio>1(Hb post-RT / Hb bef-RT) was 30 months, which was significantly longer than that in the patients with a ratio ≤1 (P<0.05). Conclusion For EC patients, Hb concentration in pre-RT and post-RT was related to local control rate and long-term survival rate, and it is worthy of further study.

Key words: hemoglobin, esophageal cancer, local control, long-term survival