Abstract:

Objective To analyze the value of urinary kidney injury molecules (uKIM-1) and urinary hepatic fatty acid binding protein(uL-FABP) in predicting early renal damage in patients with pregnancy induced hypertension syndrome(PIH). Methods Totally 100 PIH inpatients from October 2019 to October 2021 were included in the study, the patients were divided into renal function injury group (60 ml/min≤eGFR<90 ml/min, 42 cases) and non renal function injury group (eGFR≥90 ml/min, 58 cases) based on glomerular filtration rate(GFR). The levels of uKIM-1 and uL-FABP on admission were measured, ROC was used to analyze the predictive value of uKIM-1 and uL-FABP levels for early renal damage in PIH patients. The predictive value of uKIM-1 combined with uL-FABP on early renal damage in PIH patients were assessed by consistency analysis. Results The levels of uKIM-1 and uL-FABP were significantly higher in renal function injury group than in non renal function injury group, and the difference was statistically significant (P<0.05). The receive operating characteristic(ROC) curve analysis showed that the area under the curve(AUC) of uKIM-1 and uL-FABP in predicting early renal damage in PIH patients were 0.834 and 0.894 respectively (all P<0.05). The result of the consistency analysis showed that totally 39 positive involved out of 100 cases, with 0.929 for sensitivity, 0.931 for specificity, 0.930 for accuracy, and 0.857 for kappa. Conclusion The levels of uKIM-1 and uL-FABP can be used to predict early renal damage in PIH patients, and the combined examination can obtain better sensitivity and specificity, which has the value of clinical promotion.

Key words: hypertension, pregnancy-induced, renal insufficiency, forecasting