Abstract:

Objective To explore the incidence and risk factors for venous thromboembolism (VTE) in 145 patients with diffuse large B-cell lymphoma (DLBCL). Methods Totally 145 DLBCL patients admitted to our hospital from May 2016 to August 2019 were selected and divided into a VTE group (n=22) and a non-VTE group (n=123) as the results in ultrasonography for VTE. Multivariate Logistic regression was used to analyze the risk factors for VTE in DLBCL patients, as well as the difference of recurrence rate, recurrence-free survival rate, and overall survival rate between groups. Results The independent risk factors for VTE were intravenous catheterization, non-complete remission (non-CR) after 3-4 courses of chemotherapy, D-dimer level ≥1.44 μg/ml(OR=5.143, 9.000, 16.514, P<0.05). But performance status (PS) score ≥2 was considered a protective factor (OR=0.170, P<0.05); there was no significant difference in recurrence rate, recurrence-free survival rate, and overall survival rate between groups (P>0.05). Conclusion Independent risk factors for VTE in DLBCL patients were Intravenous catheterization, non-CR after 3-4 courses of chemotherapy, D-dimer ≥1.44 μg/ml, and protective factor for VTE is PS score ≥2.

Key words: lymphoma,large B-cell,diffuse, venous thromboembolism, risk factors