Abstract: ObjectiveTo study the clinical efficacy in different timing of endovascular embolization of intracranial aneurysms and to analyze the correlative factors of prognosis. MethodsA total of 121 patients with intracranial aneurysms were selected into this study between January 2012 to January 2016. All patients were divided into four groups based on the surgical time， including ultraearly group (23 cases)， early group ( 25 cases)，interval group (47 cases) and delayed group (26 cases). Embolization effect and complication rate were compared. The influence of hypertension， HuntHess grade and Fisher grade on prognosis were analyzed by unconditional logistic regression analysis. ResultsThe embolization rates in ultraearly and early groups were significantly higher than those of interval and delayed groups (P<0.01). The incidences of the postoperative limb dysfunction and cerebral vasospasm in ultraearly and early groups were significantly lower than those of interval group and delayed groups (P<0.05). Univariate analysis showed that history of hypertension， HuntHes grade， Fisher grade， multiple aneurysms and operation time were significantly correlated with the prognosis quality (P<0.05). Multivariate logistic analysis showed Fisher grade， HuntHes grade， history of hypertension and other factors were independent prognostic factors of prognosis quality (P<0.05). ConclusionEarly and ultraearly embolization of intracranial aneurysm can achieve better results， but also significantly reduce the incidences of postoperative limb dysfunction and cerebral vasospasm，meanwhile hypertension， HuntHes grade and Fisher grade were independent prognostic factors.

Key words: intracranial aneurysms, embolization, therapeutic；prognosis