Abstract: ObjectiveTo explore the relationship between homocysteine (Hcy) and ischemic cerebrovascular disease， and the effect of B vitamins intervention. MethodsPatients with ischemic cerebrovascular disease， including cerebral infarction， transient ischemic attack， were selected as observation group and normal healthy people were selected as control group. Observation group was then divided into two subgroups based on the level of Hcy: observation group 1 and observation group 2. Both subgroups had antiplatelet therapy and other conventional therapy， meanwhile， observation group 1 took additionally vitamin B6， vitamin B12 and folic acid.  The level of Hcy， PWV， CIMT before and after treatment were determined and the recurrence rate of ischemic cerebrovascular disease was compared between groups within 1 year. ResultsThe level of Hcy in patients with cerebral infarction plasma was significantly higher than that of the control group (P<0.05). Folic acid and vitamin B6， B12 can effectivly reduce the levels of Hcy， PWV and CIMT (P<0.05). The recurrence rate of ischemic cerebrovascular disease had no significant difference between subgroups within one year (P>0.05). ConclusionThere is a close correlation between the occurrence of cerebral infarction and Hcy concentration. Extensive screening of Hcy concentration in highrisk population of cerebrovascular disease and active intervention with B vitamins in people with high level of Hcy will effectively reduce the incidence of atherosclerosis and its complications.

Key words: brain infarction, cysteine, vitamins