Analysis of demographic, clinical and imaging in patients with acute cerebral infarction caused by patent foramen ovale

doi:10.3969/j.issn.1004-583X.2023.06.003

Abstract

Abstract:

Objective To analyze the demographic, clinical and imaging characteristics of patients with acute cerebral infarction(ACI) caused by patent foramen ovale(PFO). Methods From June 29, 2020 to June 15, 2022, the clinical data including their demographic characteristics (age, sex), the National Institutes of Health Stroke Scale (NIHSS) scores, serum laboratory indicators, imaging lesions (location, number and volume of lesions) were collected form 120 ACI patients with cerebral infarction caused by PFO and 120 ACI patients without PFO.The above data of the two were assessed. Resultss The ACI patients with PFO has significantly younger age ([66.00±13.75] vs [(71.50±10.75)], P <0.05), lower the NIHSS score([5.08±3.78]vs [6.89±4.29], P <0.05) and higher the serum homocysteine (Hcy) value([11.98±5.74] μmolL vs [10.04±4.40 ] μmolL, P <0.05) than those without PFO. In brain imaging, the proportion of lesions in the posterior circulation territory and the numbers of small lesions (infarct≤10mm) in ACI patients with PFO were significantly higher than those without PFO( P <0.05).Conclusion Compared with those without PFO, ACI patients with PFO mostly occurs lesions in the posterior circulation territory, and they has mainly small infarcts, relatively mild symptoms and relatively younger onset age.

Key words: foramen ovale, patent, brain infarction, cryptogenic stroke, right-to-left shunt

CLC Number:

R541.1

Zhang Xueqian, Li Yang, Xu Guodong, Lyu Peiyuan. Analysis of demographic, clinical and imaging in patients with acute cerebral infarction caused by patent foramen ovale[J]. Clinical Focus, 2023, 38(6): 500-503.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.06.003

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I6/500

Figures/Tables 3

Tab.1 Comparison of clinical baseline data between groups

组别	例数	性别[例(%)]		年龄 (岁)
组别	例数	男	女	年龄 (岁)
PFO致脑梗死组	120	74(61.7)	46(38.3)	66.00±13.75
非PFO致脑梗死组	120	69(57.5)	51(42.5)	71.50±10.75
$t$ /χ²值		0.433		4.087
$P$ 值		0.511		0.000

Tab.1 Comparison of clinical baseline data between groups

组别	例数	性别[例(%)]		年龄 (岁)
组别	例数	男	女	年龄 (岁)
PFO致脑梗死组	120	74(61.7)	46(38.3)	66.00±13.75
非PFO致脑梗死组	120	69(57.5)	51(42.5)	71.50±10.75
$t$ /χ²值		0.433		4.087
$P$ 值		0.511		0.000

Tab.2 Comparison of NIHSS and Hcy level between groups($\bar{x}±s$)

组别	例数	入院时NIHSS评分 (分)	血同型半胱氨酸 (μmol/L)
PFO致脑梗死组	120	5.08±3.78	11.98±5.74
非PFO致脑梗死组	120	6.89±4.29	10.04±4.40
$t$ 值		3.478	2.94
$P$ 值		0.001	0.004

Tab.2 Comparison of NIHSS and Hcy level between groups($\bar{x}±s$)

组别	例数	入院时NIHSS评分 (分)	血同型半胱氨酸 (μmol/L)
PFO致脑梗死组	120	5.08±3.78	11.98±5.74
非PFO致脑梗死组	120	6.89±4.29	10.04±4.40
$t$ 值		3.478	2.94
$P$ 值		0.001	0.004

Tab.3 Comparison of clinical imaging between groups[cases(%)]

组别	例数	梗死部位		梗死灶大小
组别	例数	位于前循环	位于后循环	>10 mm	≤10 mm
PFO致脑梗死组	120	44(36.7)	76(63.3)	41(34.1)	79(65.8)
非PFO致脑梗死组	120	62(51.7)	58(48.3)	56(46.7)	64(53.3)
χ²值		5.475		3.893
$P$ 值		0.013		0.033

Tab.3 Comparison of clinical imaging between groups[cases(%)]

组别	例数	梗死部位		梗死灶大小
组别	例数	位于前循环	位于后循环	>10 mm	≤10 mm
PFO致脑梗死组	120	44(36.7)	76(63.3)	41(34.1)	79(65.8)
非PFO致脑梗死组	120	62(51.7)	58(48.3)	56(46.7)	64(53.3)
χ²值		5.475		3.893
$P$ 值		0.013		0.033

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