Abstract:

Objective To explore the relationship between H-type hypertension and the severity of neurological deficits in the early acute cerebral infarction of large atherosclerosis (LAA).Methods The general information of 270 patients with acute cerebral infarction of LAA were recorded, the fasting serum homocysteine (Hcy) within 24 hours were performed in all patients. According to with or without of hypertension and serum Hcy levels, the patients were divided into H-type hypertension group (hypertension and Hcy≥10 μmol/L), simple hypertension group (only hypertension), and simple high Hcy group (only Hcy≥10 μmol/L), control group (without hypertension and elevated Hcy). National Institutes of Health Stroke Scale (NIHSS) was used to assess the severity degree of neurological deficits at admission (mild NIHSS ≤5 points, moderate to severe NIHSS> 5 points). The analysis was made for the correlation between H-type hypertension and the severity of neurological deficits in the early acute cerebral infarction of LAA.Results The incidence of H-type hypertension in patients with moderate to severe acute cerebral infarction was higher than that in patients with mild acute cerebral infarction (P<0.01); the interaction index (S)>1 of hypertension and high Hcy on the severity of neurological deficits had a positive interaction.Conclusion H-type hypertension may be a risk factor for the deterioration of neurological function in the early acute cerebral infarction of LAA, and hypertension and high Hcy have a synergistic effect on the deterioration of neurological function.

Key words: hypertension, homocysteine, brain infarction, neurologic manifestations