Abstract:

Objective To explore correlations between serum inflammatory factors, coagulation function and prognosis of neurological function in patients with acute cerebral infaretion (ACI). Methods From January 2021 to January 2022, eighty ACI patients (observation group) and 40 health examiners (control group) in the Third Hospital of Nanchang were randomly enrolled. Clinical data of two groups were assessed. Results Compared to the control group, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), hypersensitive C-reactive protein (hs-CRP), fibrinogen (Fib) and D dimer (DD) in the observation group were significantly higher, and the level of plasma thrombin time (PT) and activated partial thromboplastin time (APTT) were significantly lower (P<0.05). IL-6, TNF-α, hs-CRP, DD and Fib escalate increased consistently with ACI in mild, moderate and severe subgroups of the observation group (P<0.05). The correlation analysis showed that the level of all indexes including serum IL-6, TNF-α, hs-CRP, Fib and DD in the observation group were positively correlated with the degree of neurological impairment (r denoted 0.402, 0.420, 0.498, 0.305 and 0.473, respectively, P<0.01), neither PT nor APTT was correlated with the degree of neurological impairment (P>0.05). Conclusion Serum inflammatory factors (IL-6, TNF-α, hs-CRP) and coagulation functions (Fib, DD) are certainly related to prognosis of neurological function in ACI patients.

Key words: cerebral infarction, neurologic manifestations, serum inflammatory factors, coagulation function, prognosis