Abstract: ObjectiveTo investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and ApoB/ApoAⅠ. MethodsTwentynine patients with only snoring and 50 patients with OSAHS were enrolled. The baseline data， laboratorial index(TG， TC， HDLC， LDLC， LDLC/HDLC，ApoAⅠ， ApoB，ApoB/ApoAⅠ，Glu，UA) and sleep monitoring results (AHI) of all patients were collected. ResultsCompared with the control group，ApoB/ApoAⅠ  and  BMI were significantly increased in OSAHS group （P<0.05）. TG， TC， LDLC， HDLC， LDLC/HDLC， ApoAⅠ， ApoB， Glu， UA，age， gender and oral lipidlowering drug showed no significant difference between two groups(P>0.05). Moreover，  ApoB， ApoB/ApoAⅠ， BMI showed  linear correlation with AHI  respectively (r=0.243，r=0.298，r=0.281，respectively，P＜0.05). ConclusionObesity was a major risk factor of OSAHS， BMI and AHI were positively correlated. Compared with the control group the apoB/ApoAⅠ increased significantly in OSAHS group，  apoB and apoB/ApoAⅠ and the severity of OSAHS were positively correlated.

Key words: sleep apnea syndromes, apolipoproteins A Ⅰ, apolipoproteins B