Meta-analysis of the relationship between obstructive sleep apnea hypopnea syndrome and serum lipid levels

doi:10.3969/j.issn.1004-583X.2021.03.001

Abstract

Abstract:

Objective To systematically evaluate the correlation between obstructive sleep apnea hypopnea syndrome (OSAHS) and serum lipid levels, and to explore the clinical significance of changes in serum lipid levels of OSAHS patients. Methods PubMed, Cochrane Library, CNKI, VIP and Wanfang database were searched. The literatures and references enrolled were manually searched to find the published case-control studies on the relationship between OSAHS and serum lipid levels. The retrieval time was from the establishment of the database to December 2018. Meta-analysis was conducted with revman5.3 software after screening, extracting data and evaluating the risk of bias by two researchers independently. Results A total of 9 studies including 1473 patients, were enrolled in the screening. The results of meta-analysis showed that triglycerides (MD=0.60, 95%CI[0.54, 0.67], P<0.01) and low-density lipoprotein levels (MD=0.25, 95%CI[0.02, 0.49], P<0.01) in OSAHS patients were higher than those in control group, while the level of high-density lipoprotein (MD=-0.17, 95%CI[-0.25, -0.08], P<0.01) was lower than that in the control group. Conclusion The results of meta-analysis indicate that patients with OSAHS often have dyslipidemia. However, due to the limited number of studies and the quality of them, the above conclusions and related mechanisms still require experimental research with higher quality and larger samples to further verify.

Key words: sleep apnea syndromes, snoring disease, serum lipids, meta-analysis

CLC Number:

R563.8

Zhao Chong, Liu Zhongyang, Xu Feng, Li Huafeng. Meta-analysis of the relationship between obstructive sleep apnea hypopnea syndrome and serum lipid levels[J]. Clinical Focus, 2021, 36(3): 197-202.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.03.001

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I3/197

Figures/Tables 8

References 27

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作者	发表年份	纳入人数 (病例组/对照组)	年龄(岁)		性别(男/女,例)		观测指标
作者	发表年份	纳入人数 (病例组/对照组)	病例组	对照组	病例组	对照组	观测指标
Gruber等	2006	38/41	51.0±2.0	47.3±1.7	-	-	①②③④
Steven等	2004	61/43	49.6±1.2	47.1±1.4	-	-	①④
王莹等	2004	32/30	44.1±6.4	43.2±6.5	26/6	24/6	①②③④
Lin等	2011	154/45	48.1±14.4	47.0±12.8	91/22	38/7	①③④
Kathry等	2006	128/82	48.5±10.8	43.4±11.6	102/26	45/37	①③④
Susan等	2007	22/248	13.4±0.5	13.6±0.7	17/5	123/125	②③④
李洁等	2016	119/126	56.8±13.3	58.7±15.7	87/32	71/55	①②③④
王艳飞等	2018	32/43	53.3±4.7	56.2±3.9	17/15	23/20	①②③④
宋卫卫等	2017	235/35	-	-	193/42	20/15	①②③④

作者	发表年份	纳入人数 (病例组/对照组)	年龄(岁)		性别(男/女,例)		观测指标
作者	发表年份	纳入人数 (病例组/对照组)	病例组	对照组	病例组	对照组	观测指标
Gruber等	2006	38/41	51.0±2.0	47.3±1.7	-	-	①②③④
Steven等	2004	61/43	49.6±1.2	47.1±1.4	-	-	①④
王莹等	2004	32/30	44.1±6.4	43.2±6.5	26/6	24/6	①②③④
Lin等	2011	154/45	48.1±14.4	47.0±12.8	91/22	38/7	①③④
Kathry等	2006	128/82	48.5±10.8	43.4±11.6	102/26	45/37	①③④
Susan等	2007	22/248	13.4±0.5	13.6±0.7	17/5	123/125	②③④
李洁等	2016	119/126	56.8±13.3	58.7±15.7	87/32	71/55	①②③④
王艳飞等	2018	32/43	53.3±4.7	56.2±3.9	17/15	23/20	①②③④
宋卫卫等	2017	235/35	-	-	193/42	20/15	①②③④