Abstract: Clostrudium difficile (CD) is a major cause of hospital acquired infection. It can cause antibioticassociated diarrhea and even induce toxic megacolon and shock. Symptoms of CD infection (CDI) range from mild diarrhea to lifethreatening pseudomembranous colitis, toxic megacolon, even death. The testing of CD  usually requires a multistep algorithm (ie, glutamate dehydrogenase plus toxin A and B enzyme immunoassays). The first therapeutic step of CDI is to discontinue the administration of the inciting antibiotic agents as soon as possible. And vancomycin, fidaxomicin and metronidazole are recommended as the most effective  therapies of CDI.  As to patients suffering from CDI recurrence,  fecal microbiota transplantation is recommended.

Key words: Clostrudium infections, diagnosis, treatment