Abstract: Objective  To  investigate the clinical features and risk factors of rheumatoid arthritis（RA）related interstitial lung disease(ILD) . Methods  A total of 373 RA patients treated from January 1st 2017 to June 30th 2018 were collected.  According to the clinical manifestations and highresolution CT (HRCT) of the lungs, the patients were divided into RA with ILD  group and RA with non ILD(NILD)  group. Then the clinical features of these two groups were analyzed.Results  ①Of  373 RA patients, 229 cases had ILD and 76 cases had respiratory symptoms. ② The age, age of onset and the ratio of male and female were higher in ILD group than those in NILD group;   ③The number of swollen joints, tenderness joints, and incident of morning stiffness, cough  and postexercise shortness in ILD group were higher than those of  NILD group; ④The levels of erythrocyte sedimentation rate, white blood cell count, neutrophil count, low density lipoprotein, hypersensitive Creactive protein, urea, creatinine, uric acid, cystatin C, rheumatoid factor, anticyclic citrullinated peptide antibody in ILD were higher than those of NILD group. The levels of albumin and apolipoprotein A1 were lower than those of NILD group; ⑤ Age, number of joint involvement and antiCCP antibody were independent risk factors for RArelated ILD, and albumin was the protective factor. Conclusion  RA is easy to combine with ILD, but it is concealed. The risk factors are advanced age, heavy joint involvement and high titer antiCCP antibody.

Key words: arthritis, , rheumatoid； lung , diseases, , interstitial; , clinical characteristics, risk factors