Abstract:

Objective To explore the clinical manifestation, laboratory examination, neuroimaging examination, diagnosis and treatment of antiphospholipid syndrome (APS). Methods Collecting the clinical data of 7 patients with thrombotic APS from January 2019 throuh November 2020, retrospectively analyzed their clinical data, auxiliary examinations, treatment measures and neuroimaging. Results Seven cases of antiphospholipid antibodies were all positive, 1 case of thrombosis involved brain, kidney, lung, considering catastrophic APS, 1 case of recurrent arterial and venous thrombosis of lower extremity, 3 cases of lower extremity venous thrombosis, 3 cases of cerebral infarction. Among the cases, there were 2 cases of systemic lupus erythematosus and 1 case of ankylosing spondylitis. The treatment was treated with anticoagulation such as warfarin or rivaroxaban. One patient died of tuberculous meningitis, and the symptoms of the remaining 6 patients improved. Conclusion Thrombotic APS is characterized by venous, arterial or microvascular thrombosis, which is a very heterogeneous disease. Cerebral circulation is the most commonly affected arterial area. The treatment of thrombotic APS should assess the risk of thrombosis and treat it by stratification.

Key words: antiphospholipid syndrome, antiphospholipid antibodies, thrombosis, treatment