Relations between serum 25-(OH)D level and short stature in children

doi:10.3969/j.issn.1004-583X.2021.04.013

Abstract

Abstract:

Objective The purpose of this study is to investigate the relations between serum 25-(OH)D level and short stature in children. Methods One hundred and seventy two patients who visited the pediatric endocrine clinic of the hospital and were diagnosed to have short stature (94 males, 78 females, 8.50±3.18 years old) were retrospectively collected, 78 cases were included in the growth hormone deficiency (GHD) group, 94 cases were included in the idiopathic short stature (ISS) group according to the causes. A total of 175 healthy children (84 males and 91 females, 7.65±1.19 years old) undergoing physical examination in the hospital during the same period were selected to be controlled. The relations between serum 25-(OH) D level and short stature of children were analyzed. Results (1)The differences in the age, height and body mass of children in GHD group, ISS group and control group were statistically significant (P<0.05), the serum 25-(OH)D level in GHD group was significantly lower than that in ISS group and control group(P<0.01).The difference in serum 25-(OH)D level between different genders in ISS group (P<0.05) was a statistically significant, and serum 25-(OH)D level in male children was higher than that in female children(P=0.011).(2)The proportion of vitamin D deficiency in GHD group (30.76%, 24/78) was higher than that in ISS group (6.38%,6/94)(χ²=17.604, P<0.01). Conclusion The decreased serum 25-(OH)D level is more obvious in children with short stature, especially in children with GHD among them.

Key words: short stature, 25-hydroxy vitamin D, growth hormone deficiency, idiopathic short stature

CLC Number:

R725

Shao Na, Wang Shuo, Li Yao, Luo Xuemei, Tan Chuanmei. Relations between serum 25-(OH)D level and short stature in children[J]. Clinical Focus, 2021, 36(4): 353-356.

Add to citation manager EndNote|Ris|BibTeX

URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.04.013

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I4/353

Figures/Tables 3

References 25

[1]	Tzioumis E, Kay MC, Bentley ME, et al. Prevalence and trends in the childhood dual burden of malnutrition in low-and middle-income countries, 1990-2012[J]. Public Health Nutr, 2016,19(8):1375-1388. doi: 10.1017/S1368980016000276 pmid: 26905921
[2]	Jafari-Adli S, Qorbani M, Heshmat R, et al. Association of short stature with life satisfaction and self-rated health in children and adolescents: the CASPIAN-IV study[J]. J Pediatr Endocrinol Metab, 2016,29(11):1299-1306.
[3]	Ma J, Zhang ZX, Niu WQ, et al. Education, altitude, and humidity can interactively explain spatial discrepancy and predict short stature in 213, 795 Chinese School Children[J]. Front Pediatr, 2019,30(7):425.
[4]	Christakos S, Dhawan P, Verstuyf A, et al. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects[J]. Physiological Rev, 2016,96(1):365-408. doi: 10.1152/physrev.00014.2015 URL
[5]	Holick MF. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention[J]. Rev Endocr Metab Disord, 2017,18(2):153-165. doi: 10.1007/s11154-017-9424-1 URL
[6]	Hernigou P, Sitbon J, Dubory A, et al. Vitamin D history part Ⅲ: the “modern times”-new questions for orthopaedic practice: deficiency, cell therapy, osteomalacia, fractures, supplementation, infections[J]. Int Orthop, 2019,43(7):1755-1771. doi: 10.1007/s00264-019-04334-w URL
[7]	Gong QH, Li SX, Li H, et al. 25-Hydroxyvitamin D status and its association with sleep duration in Chinese school children[J]. Nutrients, 2018,10(8):1-9. doi: 10.3390/nu10010001 URL
[8]	中华医学会儿科学分会内分泌遗传代谢学组. 矮身材儿童诊治指南[J]. 中华儿科杂志, 2008,46(6):428-430.
[9]	Inzaghi E, Reiter E, Cianfarani S. The challenge of defining and investigating the causes of idiopathic short stature and finding an effective therapy[J]. Horm Res Paediatr, 2019,92(2):71-83. doi: 10.1159/000502901 pmid: 31578025
[10]	Misra M, Pacaud D, Petryk A, et al. Vitamin D deficiency in children and its management: review of current knowledge and recommendations[J]. Pediatrics, 2008,122(2):398-417. doi: 10.1542/peds.2007-1894 URL
[11]	Waldman LA, Chia DJ. Towards identification of molecular mechanisms of short stature[J]. Int J Pediatr Endocrinol, 2013,2013(1):19. doi: 10.1186/1687-9856-2013-19 URL
[12]	Chang SW, Lee HC. Vitamin D and health-The missing vitamin in humans[J]. Pediatr Neonatol, 2019,60(3):237-244. doi: 10.1016/j.pedneo.2019.04.007 URL
[13]	Ciresi A, Giordano C. Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess[J]. Growth Horm IGF Res, 2017,33:35-42. doi: 10.1016/j.ghir.2017.02.002 URL
[14]	Jawa A, Riaz SH, Khan Assir MZ, et al. Causes of short stature in pakistani children found at an endocrine center[J]. Pak J Med Sci, 2016,32(6):1321-1325. doi: 10.12669/pjms.326.11077 pmid: 28083018
[15]	Ewelina WS, Anna SE, Anna M, et al. The relationship between alkaline phosphatase and bone alkaline phosphatase activity and the growth hormone/insulin-like growth factor-1 axis and vitamin D status in children with growth hormone deficiency[J]. Acta Biochim Pol, 2018,65(2):269-275.
[16]	Qin X, Wang X. Role of vitamin D receptor in the regulation of gene expression[J]. Acta pharm Sin B, 2019,9(6):1087-1098. doi: 10.1016/j.apsb.2019.03.005 URL
[17]	Ciresi A, Cicciò F, Giordano C. High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment[J]. J Endocrinol Invest, 2014,37(7):631-638. doi: 10.1007/s40618-014-0084-7 URL
[18]	Hamza RT, Hamed AI, Sallam MT. Vitamin D status in prepubertal children with isolated idiopathic growth hormone deficiency: effect of growth hormone therapy[J]. J Investig Med, 2018,66(5):1-8.
[19]	Witkowska-Sędek E, Stelmaszczyk-Emmel A, Kucharska A, et al. Association between vitamin D and carboxy-terminal cross-linked telopeptide of type i collagen in children during growth hormone replacement therapy[J]. Adv Exp Med Biol, 2018,1047:53-60. doi: 10.1007/5584_2017_109 pmid: 28936809
[20]	Hansen TB, Brixen K, Vahl N, et al. Effects of 12 months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study[J]. J Clin Endocrinol Metab, 1996,81(9):3352-3359.
[21]	Gertner JM, Horst RL, Rasmussen H, et al. Parathyroid function and vitamin D metabolism during human growth hormone replacement[J]. J Clin Endocrinol Metab, 1979,49(2):185-188. doi: 10.1210/jcem-49-2-185 URL
[22]	Domené HM, Scaglia PA, Martínez AS, et al. Heterozygous IGFALS gene variants in idiopathic short stature and normal children: impact on height and the IGF system[J]. Horm Res Paediatr, 2013,80(6):413-423. doi: 10.1159/000355412 URL
[23]	Cohen P, Germak J, Rogol AD, et al. Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children[J]. J Clin Endocrinol Metab, 2010,95(5):2089-2098. doi: 10.1210/jc.2009-2139 URL
[24]	Wang W, Luo XP, Cai LX, et al. Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature[J]. Genet Mol Res, 2015,14(3):10507-10514. doi: 10.4238/2015.September.8.12 pmid: 26400282
[25]	Emmanouilidou E, Galli-Tsinopoulou A, Kyrgios I, et al. Common VDR polymorphisms and idiopathic short stature in children from northern Greece[J]. Hippokratia, 2015,19(1):25-29.

组别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
对照组	175	7.65±1.19	127.91±10.23	26.79±6.93	16.17±2.42	25.56±4.10
GHD	78	9.25±2.69	121.78±15.04	24.98±9.49	16.38±2.92	22.85±3.93
ISS	94	7.89±3.43	116.76±19.05	23.49±10.39	16.66±3.36	25.43±3.99
F值		12.614	19.586	4.694	0.952	13.231
P值		0.00	<0.05	0.01	>0.05	0.00

组别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
对照组	175	7.65±1.19	127.91±10.23	26.79±6.93	16.17±2.42	25.56±4.10
GHD	78	9.25±2.69	121.78±15.04	24.98±9.49	16.38±2.92	22.85±3.93
ISS	94	7.89±3.43	116.76±19.05	23.49±10.39	16.66±3.36	25.43±3.99
F值		12.614	19.586	4.694	0.952	13.231
P值		0.00	<0.05	0.01	>0.05	0.00

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	46	9.47±4.08	121.16±15.87	23.58±8.20	15.72±2.23	23.43±4.08
女	32	8.88±2.09	122.69±13.97	26.99±10.91	17.31±3.51	22.01±3.59
t值		1.017	-1.498	-1.576	-2.442	1.582
P值		0.002	0.178	0.084	0.001	0.572

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	46	9.47±4.08	121.16±15.87	23.58±8.20	15.72±2.23	23.43±4.08
女	32	8.88±2.09	122.69±13.97	26.99±10.91	17.31±3.51	22.01±3.59
t值		1.017	-1.498	-1.576	-2.442	1.582
P值		0.002	0.178	0.084	0.001	0.572

性别	例数	年龄(岁)	身高(cm)	体质量(kg)	BMI(kg/m²)	25-(OH)D( ng/ml)
男	48	8.01±3.82	117.09±20.44	23.56±10.48	16.50±2.96	25.53±4.70
女	46	7.76±3.00	116.42±17.70	23.42±10.41	16.83±3.77	25.32±3.13
t值		0.353	0.169	0.066	-0.485	0.251
P值		0.006	0.218	0.998	0.058	0.011