Abstract: Objective By analyzing the clinical characteristics of subacute combined spinal core degenerationin (SCD),to improve recognition and early diagnosis.Methods The general clinical data, nerve function defect situation, and related examination results were collected and analyzed retrospectively in 103 patients with clinically confirmed SCD.Results All 103 patients had nerve function defect. Reduced hemoglobin was found in 48 of 103 cases (46.6%), reduced mean corpuscular volume in 59 of 103 cases(57.3%) and reduced mean corpuscular hemoglobin in 62 of 103 cases(60.2%). The serum vitamin B12 was lower than before the disease onset in 52 of 93 cases (55.9%). 46.1% in 91 patients were observed with the lower folic acid level. Elevated homocysteine and cerebrospinal fluid protein level were observed in 80.6% and 27% patients respectively. 58 of 79 patients(73.4%) showed abnormal changes in electromyography, 93.3% patients(56/60) the abnormal somatosensory evoked potentials (SEP),49.4% of the patients were found lesions by magnetic resonance imaging,the lesions involved thoracic cord, cervical cord and cerebral white matter.Conclusion The clinical manifestations and auxiliary examination of SCD are diversified. The high rate in misdiagnosis existed, comprehensive consideration played an important role in the diagnosis of SCD.