Abstract: ObjectiveTo explore the relationship between pneumonia mycoplasma infection and Kawasaki disease and coronary artery lesions. MethodsA total of 180 children with Kawasaki disease were chosen as research group， the chidren with rash disease during the same period excluding lung disease were selected as control  group. In research group，MPIgM was detected from peripheral blood by indirect immunofluorescence method， Mycoplasma pneumonia total antibody was detected by passive agglutination method; According to whether the children was infected with Mycoplasma pneumoniae， the research group was separated into infection group and noninfection group.  Before and after gamma globulin (IVIG)  treatment，comparison was made in peripheral blood leukocytes， platelets， Creactive protein， number of neutrophils， blood sedimentation， the incidence of coronary artery lesions and the hospital stay; According to whether the occurrence of coronary artery lesions， the research group was divided into coronary artery lesions group and noncoronary artery lesions group， and the incidence of Mycoplasma pneumoniae infection was compared. ResultsMycoplasma pneumoniae infection rate was significantly higher in research group than in control group (P<0.05); The incidences of Creactive protein， number of neutrophils， blood sedimentation， expansion of coronary artery disease was significantly different between infection group and non infection group  (P<0.05); The incidence of  Mycoplasma pneumoniae infection was significantly higher in coronary artery lesions group than in noncoronary artery lesions group (P<0.05).ConclusionThe pathogenesis of Kawasaki disease may be associated with the infection of  Mycoplasma pneumoniae， and the infection also has certain impact on the occurrence of coronary artery lesions.

Key words: mucocutaneous lymph node syndrome, mycoplasma pneumoniae, coronary artery disease