Abstract:

Objective Mean platelet volume(MPV) and platelet distribution width(PDW) are related with platelet function, which may be more sensitive indicators of abnormal platelet function compared with the number of platelets(PLT). the article aims to study the changes and clinical significance of platelet parameters in Kawasaki disease(KD). Methods MPV, PDW, PLT, white blood cell(WBC), C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR) were counted and analyzed from 439 KD patients and 261 healthy children, retrospectively. KD patients were divided into two groups depending on the complex degree of coronary arterial lesions (CAL): coronary artery injury group (CALs group), no coronary artery injury group (no-CALs group). On the other hand, and the difference of complete Kawasaki disease(cKD) and incomplete Kawasaki disease(iKD) were compared. Results Compared with healthy controls, WBC, PLT, CRP and ESR in KD children significantly increased (P<0.01), while MPV and PDW significantly decreased (P<0.01, P<0.05). Compared with cKD patients, MPV and PDW in iKD patients were significantly lower (P=0.003, 0.014). Conclusion This study suggested that MPV and PDW were reduced in acute-phase, especially in iKD. Therefore, low-levels of MPV and PDW may be helpful for the diagnosis of iKD.

Key words: mucocutaneous lymph node syndrome, mean platelet volume, ultrasonography, Doppler, color